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Join an NIEHS Study
National Institute of Environmental Health Sciences

Studies

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Studies Open for Recruitment

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Adult and Juvenile Myositis

This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their causes, and the immune system changes and medical problems associated with them. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability.
This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their causes, and the immune system changes and medical problems associated with them. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability.
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Body Weight & Puberty Study

Do Overweight Girls Start Puberty Too Soon?

Girls seem to be going through puberty a lot earlier these days. Doctors think it may be related to body weight. Are you concerned that your daughter is overweight and may start puberty too soon?
Girls seem to be going through puberty a lot earlier these days. Doctors think it may be related to body weight. Are you concerned that your daughter is overweight and may start puberty too soon?
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Calcinosis Study

This study is a clinical trial of intravenous sodium thiosulfate, a drug being tested for efficacy and safety in patients who have moderate to extensive calcinosis associated with juvenile and adult dermatomyositis.
This study is a clinical trial of intravenous sodium thiosulfate, a drug being tested for efficacy and safety in patients who have moderate to extensive calcinosis associated with juvenile and adult dermatomyositis.
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CaREFREE: Nutrition and Menstruation

Many women develop irregular menstrual cycles which may make it difficult to become pregnant and increase the risk of osteoporosis. Why do exercise and diet have this effect in some women but not others? This study will help us understand how nutrition, exercise, and the environment affect women's reproductive cycles.
Many women develop irregular menstrual cycles which may make it difficult to become pregnant and increase the risk of osteoporosis. Why do exercise and diet have this effect in some women but not others? This study will help us understand how nutrition, exercise, and the environment affect women's reproductive cycles.
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E-Cigs and Smoking

Researchers are trying to develop new biomarkers of tobacco smoke exposure and e-cigarette use.
Researchers are trying to develop new biomarkers of tobacco smoke exposure and e-cigarette use.
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EPR: DNA & Your Environment

The Environmental Polymorphisms Registry (EPR) is a long-term initiative to collect approximately 20,000 DNA samples from individuals. These DNA samples will be used to examine risk factors for common health conditions such as heart disease, cancer, diabetes, asthma, and Alzheimer’s disease.
The Environmental Polymorphisms Registry (EPR) is a long-term initiative to collect approximately 20,000 DNA samples from individuals. These DNA samples will be used to examine risk factors for common health conditions such as heart disease, cancer, diabetes, asthma, and Alzheimer’s disease.
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Immunity Cells in Blood

What Is the Response of Immune Cells From the Bloodstream?

The Immunity Cells in Blood Study aims to determine the response of immune cells from the bloodstream. This study will investigate the response of immune cells to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them.
The Immunity Cells in Blood Study aims to determine the response of immune cells from the bloodstream. This study will investigate the response of immune cells to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them.
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MYORISK Study

Do you have polymyositis or dermatomyositis?

This study intends to investigate the genetic and environmental risk factors involved in the development of myositis, an autoimmune muscle disease that causes chronic muscle weakness.
This study intends to investigate the genetic and environmental risk factors involved in the development of myositis, an autoimmune muscle disease that causes chronic muscle weakness.
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Myositis in Military Personnel

Do you have myositis and have served in the military?

This study attempts to determine if environmental and geographic exposures may be related to the development of myositis during military service and to obtain an initial understanding of the possible mechanisms involved.
This study attempts to determine if environmental and geographic exposures may be related to the development of myositis during military service and to obtain an initial understanding of the possible mechanisms involved.
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NHALES: Asthma Study

Get Your Asthma Under Control

NHALES stands for Natural History of Asthma with Longitudinal Environmental Sampling. Your participation in the NHALES Study will contribute to research on how the environment affects the human body and asthma. Please consider joining today.
NHALES stands for Natural History of Asthma with Longitudinal Environmental Sampling. Your participation in the NHALES Study will contribute to research on how the environment affects the human body and asthma. Please consider joining today.
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Rheumatic Disorders in Siblings

Do you have an autoimmune disease?

The research team will study the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, in which one has the disease and the other does not.
The research team will study the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, in which one has the disease and the other does not.
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RSV Infection and Asthma

NIEHS scientists will explore whether there is a difference in lung cells from healthy and asthmatic participants and how these cells respond to exposure to respiratory syncytial virus (RSV), a very common virus that leads to cold-like symptoms. The study will also evaluate if a protein in lung cells called TGF-Beta increases risk of infection with RSV.
NIEHS scientists will explore whether there is a difference in lung cells from healthy and asthmatic participants and how these cells respond to exposure to respiratory syncytial virus (RSV), a very common virus that leads to cold-like symptoms. The study will also evaluate if a protein in lung cells called TGF-Beta increases risk of infection with RSV.
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Sample Collection Registry

Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies. The samples will be used to determine if new tests are sufficiently valid and precise to be used in research studies and for quality control purposes.
Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies. The samples will be used to determine if new tests are sufficiently valid and precise to be used in research studies and for quality control purposes.

Open Studies By Invitation Only

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Inflammatory Response to DNA Damage

The gene p53 suppresses cancer and inflammation in the body, and NIEHS researchers speculate that changes in p53 lead to changes in inflammation and the ability to repair DNA damage. This study wants blood samples from participants to find out how the changes in p53 lead to these conditions.
  • Status: Open
  • Sex: Both
  • Age: 18 - 45
  • Compensation:
  • Location: Durham, NC
The gene p53 suppresses cancer and inflammation in the body, and NIEHS researchers speculate that changes in p53 lead to changes in inflammation and the ability to repair DNA damage. This study wants blood samples from participants to find out how the changes in p53 lead to these conditions.
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Inflammatory Response to Endotoxin

Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body’s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancer.
  • Status: Open
  • Sex: Both
  • Age: 18+
  • Compensation:
  • Location: Durham, NC
Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body’s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancer.
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Metabolic Disease

NIEHS Researchers will look at how differences in people’s genes may cause their body to respond in different ways to glucocorticoids. Glucocorticoids are hormones made by the human body that are essential for life but in excess may cause diseases such as obesity and diabetes.
  • Status: Open
  • Sex: Both
  • Age: 18+
  • Compensation:
  • Location: Durham, NC
NIEHS Researchers will look at how differences in people’s genes may cause their body to respond in different ways to glucocorticoids. Glucocorticoids are hormones made by the human body that are essential for life but in excess may cause diseases such as obesity and diabetes.
Studies Not Currently Recruiting

Can’t Find the Right Study For You?

If you didn’t find an NIEHS study to join, there are other studies you can consider. Visit  ClinicalTrials.gov  and  ResearchMatch.org.