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Environmental Impact on Children’s Hormones and Reproductive Health

Studies Seeking Participants Icon Studies Seeking Participants Location icon Residents of North Carolina 8-17 Ages 8-17 Gender Icon All Genders Interested in Enrolling?

Part of the Observation of Environment and Reproductive Endocrine Effects Study (OBSERVE Study)

The purpose of this study is to research how the environment may affect a child’s hormones and reproductive system. The study will focus on health conditions such as early or delayed puberty, irregular menstrual periods, and polycystic ovarian syndrome (PCOS).

Who Can Participate?

  • Children from age 8 to 17 years old.
  • Confirmed or suspected diagnosis of endocrine or reproductive disorders.
  • Able to travel to Research Triangle Park, North Carolina.

What Is Required?

  • Study visits every 12-15 months up to age 23 for clinical care.
  • Medical history, physical exams, blood and urine samples, answering questionnaires.
  • Specialty testing measuring body composition and metabolism, if needed.

What Are the Advantages for Participants?

  • Evaluation and consultation by a specialist to confirm the diagnosis.
  • Individualized medical care and treatment at no cost.
  • Clinical laboratory tests, X-rays, and ultrasounds may be available at no cost.

Compensation is provided upon completion of each study visit.

Who Is Running the Study?

A team, led by Skand Shekhar, M.D., Janet Hall, M.D., and Natalie Shaw, M.D., from the National Institute of Environmental Health Sciences Clinical Research Unit in Research Triangle Park, North Carolina.

Lead Researchers

Skand Shekhar, M.D., M.H.Sc.

Skand Shekhar, M.D., M.H.Sc.

Tel 301-451-1866
skand.shekhar@nih.gov
Learn More About Skand Shekhar, M.D., M.H.Sc.

Skand Shekhar, M.D., D.A.B.I.M., is a clinician investigator in endocrinology and reproduction with a special interest in studying the relationship between metabolism and reproductive disorders. As the deputy leader of the Reproductive Physiology and Pathophysiology group led by Janet E. Hall, M.D., M.S. at NIEHS, Shekhar cares for patients with metabolic and genetic disorders of reproductive function, including idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome, puberty disorders, menstrual disorders, and polycystic ovarian syndrome (PCOS). His research involves studying the interaction between lifestyle, sleep, diet, and the hypothalamic-pituitary gonadal axis in humans. With a keen interest in neuroendocrinology, he studies the interaction between stress (cortisol), thyroid, and reproductive axes. He is developing clinical trials to enhance our understanding of sleep, metabolism, and reproductive endocrinology interplays. Some of his published work in this field has studied rare neoplasms such as Cushing syndrome and Erdheim-Chester disease.

Research Webpage

Janet E. Hall, M.D., M.S.

Janet E. Hall, M.D., M.S.

Tel 984-287-3647
janet.hall@nih.gov
Learn More About Janet E. Hall, M.D., M.S.

Janet E. Hall, M.D., M.S. is an internationally known clinician and clinical researcher. She received her Masters of Medical Sciences in exercise physiology and her M.D. and Internal Medicine training at McMaster University in Ontario, Canada. She completed her training in Endocrinology and Metabolism at Massachusetts General Hospital in Boston and rose to the rank of Professor of Medicine at Harvard Medical School. She had continuous NIH extramural grant funding until moving to the NIEHS intramural program in 2015. Hall was elected to the Association of American Physicians in recognition of her contributions to both the science and academics of medicine and, as a leader in the field, is a former President of the Endocrine Society.

Watch Video

Research Webpage

Natalie D. Shaw, M.D., MMSc.

Natalie D. Shaw, M.D., MMSc.

Tel 984-287-3716
natalie.shaw@nih.gov
Learn More About Natalie D. Shaw, M.D., MMSc.

Natalie D. Shaw, M.D., M.M.Sc. received a B.S. from Cornell University, an M.D. from the State University of New York (SUNY) at Buffalo, and a Masters in Medical Sciences (MMSc) from Harvard Medical School. She completed her pediatrics residency at Children's Hospital of Pittsburgh, a pediatric endocrinology fellowship at Boston Children's Hospital, and a clinical research fellowship in the Reproductive Endocrine Unit at Massachusetts General Hospital.

In 2015, Shaw was one of five junior researchers selected as a Lasker Clinical Research Scholar by the National Institutes of Health. The Lasker program is a joint partnership between the NIH and the Lasker Foundation designed to support a small number of exceptional clinical researchers in the early stages of their careers. Its goal is to promote the development of physician-scientists as they transition to fully independent positions. When Shaw joined NIEHS in September 2015, she became the first Lasker Scholar in the history of the institute.

Research Webpage

For More Information About This Study

  • Call: 1-855-MYNIEHS (1-855-696-4347)

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Last Reviewed: March 25, 2024