This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their causes, and the immune system changes and medical problems associated with them. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability.
This study is a clinical trial of intravenous sodium thiosulfate, a drug being tested for efficacy and safety in patients who have moderate to extensive calcinosis associated with juvenile and adult dermatomyositis.
The goal of this study is to learn more about the body’s regulation of puberty and reproduction. Scientists will study people who have an abnormality in certain hormone levels, which may result
in specific differences in fetal development, irregular timing of puberty, or abnormal fertility.
NHALES stands for Natural History of Asthma with Longitudinal Environmental Sampling. Your participation in the NHALES Study will contribute to research on how the environment affects the human body and asthma. Please consider joining today.
The gene p53 suppresses cancer and inflammation in the body, and NIEHS researchers speculate that changes in p53 lead to changes in inflammation and the ability to repair DNA damage. This study wants blood samples from participants to find out how the changes in p53 lead to these conditions.
Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body’s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancer.