The goal of this study is to learn more about the body’s regulation of puberty and reproduction. Scientists will study people who have an abnormality in certain hormone levels, which may result in specific differences in fetal development, irregular timing of puberty, or abnormal fertility.
Because we are studying how these disorders are inherited within families, participation of parents, siblings, and children, if applicable, is strongly encouraged.
Who Can Participate?
You may be eligible to participate in this study if you:
- Began early puberty before age 7.
- Had late or no puberty by age 14.
- Had normal puberty with low hormone levels.
- Had loss of reproductive activity sometime after puberty.
What Is Required?
- Completing online medical questionnaires.
- Providing a detailed family history.
- Taking a scratch-and-sniff smell test.
- Giving a blood sample or, in some cases, a saliva sample.
- Completing a one-time visit at a study location or your doctor’s office.
Who Is Running the Study?
A team, led by Natalie Shaw, M.D., at the National Institute of Environmental Health Sciences Clinical Research Unit in Research Triangle Park, North Carolina.
Where Is the Study Being Held?
You may enroll at the NIEHS Clinical Research Unit in Research Triangle Park, North Carolina; the Clinical Center at the National Institutes of Health in Bethesda, Maryland; or your local doctor’s office.
Lead Researchers
Natalie D. Shaw, M.D., MMSc.
natalie.shaw@nih.gov
Natalie D. Shaw, M.D., M.M.Sc. received a B.S. from Cornell University, an M.D. from the State University of New York (SUNY) at Buffalo, and a Masters in Medical Sciences (MMSc) from Harvard Medical School. She completed her pediatrics residency at Children's Hospital of Pittsburgh, a pediatric endocrinology fellowship at Boston Children's Hospital, and a clinical research fellowship in the Reproductive Endocrine Unit at Massachusetts General Hospital.
In 2015, Shaw was one of five junior researchers selected as a Lasker Clinical Research Scholar by the National Institutes of Health. The Lasker program is a joint partnership between the NIH and the Lasker Foundation designed to support a small number of exceptional clinical researchers in the early stages of their careers. Its goal is to promote the development of physician-scientists as they transition to fully independent positions. When Shaw joined NIEHS in September 2015, she became the first Lasker Scholar in the history of the institute.
Research Webpage
For More Information About This Study
- Call: 1‑855‑MYNIEHS (1‑855‑696‑4347)
- Email: myniehs@nih.gov
- Protocol Number: 12-E-0049
- Study Background and Protocols
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